KPRO (protrexed) for Lung Cancer

KPRO (protrexed) is a novel oral prodrug of the approved injectable drug pemetrexed (Alimta®).  A new oral folate inhibitor is highly desirous in treating lung cancer and autoimmune diseases. However, there are no good oral folate inhibitor options available besides methotrexate, which is a 1950s era drug associated with many adverse events. Protrexed has the potential to be the best in class oral folate inhibitor.